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Saying ‘No’ to a Treaty Ban, ‘Yes’ to Nuclear Weapons Tests

Can you find the seven countries the United States is bombing? US attacks often hit civilians with Reaper and Predator drones, Cruise missiles, depleted uranium munitions, and even a 21,600-pound “Massive Ordnance Air Blast”device, a version of fuel-air explosive or “thermobaric” bomb, that was tested on Afghanistan April 13.

By John LaForge

Last week the Air Force shot a Minuteman rocket off California toward the Martial Islands, but the government refused to join in treaty negotiations for a ban on nuclear weapons. Using a blizzard of hypocrisy and self-contradiction, US Ambassador to the United Nations Nikki Haley explained March 27 why the US would boycott the “treaty ban” negotiations.

Amb. Haley said about US nuclear weapons, “[W]e can’t honestly say that we can protect our people by allowing the bad actors to have them, and those of us that are good, trying to keep peace and safety not to have them.” North Korea’s president could have said the same thing about his six or seven nuclear warheads, especially in view of the US “trying to keep peace and safety” using bombs and missiles against seven countries — Iraq, Afghanistan, Syria, Pakistan, Yemen, Somalia, and Libya — and the joint US/S. Korea war exercises off the Korean peninsula.

Ambassador Haley managed to avoid being two-faced on one level. Joining the ban treaty talks would have been tactless and seamy while her colleagues in the war department were preparing a series of nuclear weapons tests. An April 13 test, at the Tonopah bombing range in Nevada, was of the so-called “B61-12,” a new H-bomb still in development and scheduled to go into production after 2022.

Jackie Cabasso, of the Western States Legal Foundation, explained April 20, “In 1997… President Bill Clinton signed Presidential Directive-60, reaffirming the threatened first use of nuclear weapons as the ‘cornerstone’ of US national security.… President Obama left office with the US poised to spend $1 trillion over the next 30 years to maintain and modernize its nuclear bombs and warheads…. Over the past couple of years, the US has conducted a series of drop tests of the newly modified B61-12 gravity bomb…. Each new bomb will cost more than twice its weight in solid gold.” Of the 480 B61s slated to become B61-12s, about 180 are scheduled to be placed at six NATO bases in Europe.

Another test, April 26 from Vandenberg Air Force Base in Calif., launched a modernized Minuteman-3 long-range ballistic missile. (Nukewatch co-directors Arianne Peterson, Bonnie Urfer and I recently finished NUCLEAR HEARTLAND, a book about these very rockets.) This was to be followed by another Minuteman-3 test fired at the Martial Islands May 3.

US: “We are prepared to use nuclear weapons”

 As on Feb. 21 and Feb. 25, 2016, Vandenberg regularly tests Minuteman-3s. Deputy Pentagon Chief Robert Work said then the US had conducted “at least” 15 since January 2011. Before the Feb. 25 test Mr. Work said, “And that is a signal … that we are prepared to use nuclear weapons in defense of our country if necessary.” This is the Big Lie, since using nuclear weapons only produces massacres, and massacres are never defensive.

Jason Ditz put the rocket tests in context April 26 at antiwar.com: “Everywhere and (mostly) without exception, the test of an intercontinental ballistic missile (ICBM) would be angrily condemned by the United States as a dangerous provocation, and the firing of a nuclear-capable rocket would be treated as tantamount to an act of war. Not today [April 26], of course, when the missile in question was test-fired from California by the United States flying some 4,000 miles before hitting a test target near the Marshall Islands. The missile was identified as a Minuteman III, a nuclear-capable weapon of which the US has 450 in service.”

The two times Amb. Haley flubbed her March 27 “peace and safety” speech were alarming. Haley stumbled once saying: “We would love to have a ban on nuclear treat… nuclear weapons.” A ban on nuclear treaties is more like what Amb. Haley’s bosses do want, so she didn’t mis-speak later (and did not correct herself) when she said: “One day we will hope that we are standing here saying, ‘We no longer need nuclear weapons.’” But today she doesn’t even hope to be saying such a thing. A trillion dollars is very big business.

Instead, the United States is relentlessly bombing and rocketing, hitting civilians with drones, Cruise missiles, depleted uranium munitions, and even a 21,600-pound “Massive Ordnance Air Blast” or MOAB bomb, also tested April 13 but against caves Afghanistan,. This ghastly “thermobaric” fuel-air-explosive (FAE) has the mass of five Lincoln Continentals, and reportedly killed 95 people including a teacher and his son. One Defense Intelligence Agency report uncovered by Human Rights Watch said that because “shock and pressure waves cause minimal damage to brain tissue…it is possible that victims of FAEs are not rendered unconscious by the blast, but instead suffer for several seconds or minutes while they suffocate.” Such is the peace and safety from those of us that are good.

On March 29, two days after her UN performance, Amb. Haley spoke to the Council on Foreign Relations and cleared up any confusion our globalized bombings might be causing. Haley declared, “The United States is the moral conscience of the world.” Yes Ms. Parker, “And I am Marie of Romania.”

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Dirty Bombs, Undeclared Wars Raise Prospect of US Criminal Culpability

US Uranium Weapons Used in Syria

Nukewatch Quarterly  Winter 2016-17

In October, the Pentagon admitted it used “depleted” uranium weapons in attacks inside Syria—violating its public promise last year that it would not use DU there, and contradicting the government’s promise that US bombing is done in defense of the Syrian people, according to the International Campaign to Ban Uranium Weapons.

US military officials have repeatedly assured the public that US uranium munitions are not known to cause health problems. Made from waste uranium-238—left from H-bomb and reactor fuel production—the heavy shells are called “depleted uranium” or DU. Ironically, the best evidence that DU weapons are dangerously toxic and radioactive, comes from the Pentagon itself. A June 1995 report to Congress by the Army’s Environmental Policy Institute (AEPI) concluded: “Depleted uranium is a radioactive waste and, as such, should be deposited in a licensed repository.”

Military studies done in 1979, ‘90, ‘93, ‘95 and ‘97, make clear that uranium weapons are chemically toxic, alpharadiation-emitting poisons that are a danger to target populations and to invading/occupying US forces alike. In spite of this cautionary written record, the military has been shooting its radioactive waste all over the world: into population centers in Iraq in 1991 (380 tons), in Afghanistan in 2001 (amounts unknown); in Bosnia in 1994-‘95 (five tons); in Kosovo in 1999 (10 tons), in Iraq again in 2003 (170 tons); and now in Syria.

The AEPI report above also says that DU has the potential to generate “significant medical consequences” if it enters the body. The Army’s Office of the Surgeon General, in its Aug. 16, 1993 “Depleted Uranium Safety Training Manual,” says that the expected effects of DU exposure include a possible increase of cancer and kidney damage.

The manual also warns, “When soldiers inhale or ingest DU dust, they incur a potential increase in cancer risk … (lung or bone) and kidney damage.” The Army’s Mobility Equipment, Research & Development Command reported way back in 1979 that, “Not only the people in the immediate vicinity but also people at distances downwind from the fire are faced with potential over exposure to air-borne uranium dust.” This uranium “dust” is generated when DU shells hit and burn through hard targets like tanks or armored vehicles. The uranium is spread for miles by the wind, contaminating everything is its path including food, water, soil, schools, hospitals, etc., and DU is radioactive forever, or ten times 4.5 billion years, whichever comes first.

In 1990, the Army’s Armaments, Munitions and Chemical Command radiological task group said that DU is a “low level alpha radiation emitter … linked to cancer when exposures are internal, [and] chemical toxicity causing kidney damage.” It added that “there is no dose so low that the probability of effect is zero.”

With evidence of its radio-toxicity so clear and redundant, any use of uranium weapons today appears to flaunt the military’s own Field Manual prohibition— absolute and universal—against the use of poison or poisoned weapons.

Historical disregard revisited

The military has a long history of deliberately exposing US citizens and others to deadly risks without their knowledge or consent, beginning with the open-air nuclear bomb tests it knew would contaminate vast areas.

The Atomic Energy Commission (AEC) chose not to evacuate or even warn downwind populations it knew would be hard-hit by radioactive fallout. (“Fallout risk near atom tests was known, documents show,” New York Times, March 15, 1995.) These bomb tests exposed Nevada Test Site workers to levels of radiation that the AEC knew could cause harm, but the agency chose not to reduce workers’ exposures or to even inform them of the risks because doing so would have scandalized and halted the bombing tests. (“Records say workers faced high radiation: Suit contends US used no safeguards,” St. Paul Pioneer Press, Dec. 14, 1989.)

Likewise, the government refused to inform some 600,000 H-bomb factory workers that workplace radiation exposures posed serious health risks, although enough was known about radiation to warn them in 1948. (“N-plant workers not told of risks: Report says US arms program exposed many to radiation,” Associated Press, Dec. 19, 1989.) Between 1944 and 1974, “medicalized” human radiation experiments were even conducted on unwitting US citizens, 16,000 of them. (The Plutonium Files, by Eileen Welsome, Delta, 1999.)

Today, the Pentagon extends this ghastly history into Syria where it is deliberately exposing human beings to weaponized radiation that it knows can cause cancer and other diseases. As if the undeclared, unconstitutional war in Syria weren’t unlawful enough, now add the crime of using poison in violation of military law, the Hague Regulations of War on Land, and the Geneva Conventions.

Arguing that uranium weapons are poison, a group of four non-lawyers, myself included, convinced a Minneapolis jury in 2004 that AlliantTechsystems Corporation’s manufacture of the shells is unlawful, and potentially criminal enough to excuse a misdemeanor trespass. We argued our minor offense was justified in order to prevent the greater harm of DU weapons production. The use of poison in war is always prohibited, as is the case with gas warfare and torture. This latest US government crime of war must be condemned in the harshest terms. —JL

For more information on DU weapons and the global effort to have them banned, see ICBUW.org.

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US Uranium Weapons Have Been Used in Syria

This month, the Pentagon admitted it has used uranium weapons in attacks inside Syria — violating its public promise last year that it would not use DU there, and contradicting the claim that US bombing is done in defense of the Syrian people, according to the Int’l Campaign to Ban Uranium Weapons.

Like the Pentagon’s past denials of the dangers of the chemical weapon Agent Orange, US military officials still claim publicly that its uranium weapons are not known to cause health problems. Made from waste uranium-238 — left from H-bomb and reactor fuel production — it is called “depleted” uranium (DU) but is only “depleted” of U-235. Ironically, the best evidence that it is dangerously toxic and radioactive — contrary to press pronouncements — comes from the Pentagon itself. A June 1995 report to Congress by the Army’s Environmental Policy Institute (AEPI) concluded: “Depleted uranium is a radioactive waste and, as such, should be deposited in a licensed repository.”

Military studies done in 1979, ‘90, ‘93, ‘95 and ‘97, make clear that uranium weapons are chemically toxic, alpha-radiation-emitting poisons that are a danger to target populations and to invading/occupying US forces alike. In spite of this cautionary written record, the military has been shooting its radioactive waste all over the world: into population centers in Iraq in 1991 (380 tons), in Afghanistan in 2001 (amounts unknown); in Bosnia in 1994-‘95 (five tons); in Kosovo in 1999 (10 tons), in Iraq again in 2003 (170 tons); and now in Syria.

The AEPI report above also says that DU has the potential to generate “significant medical consequences” if it enters the body. The Army’s Office of the Surgeon General, in its Aug. 16, 1993 “Depleted Uranium Safety Training Manual,” says that the expected effects of DU exposure include a possible increase of cancer, and kidney damage. The manual also warns, “When soldiers inhale or ingest DU dust, they incur a potential increase in cancer risk … (lung or bone) and kidney damage.”

The Army’s Mobility Equipment, Research & Development Command reported way back in 1979 that, “Not only the people in the immediate vicinity but also people at distances downwind from the fire are faced with potential over exposure to air-borne uranium dust.” This uranium “dust” is generated when DU shells hit and burn through hard targets like tanks or armored vehicles. The uranium is spread for miles by the wind, contaminating everything is its path including food, water, soil, schools, hospitals, etc., and DU is radioactive forever, or ten times 4.5 billion years, whichever comes first.

In 1990, the Army’s Armaments, Munitions and Chemical Command radiological task group said that DU is a “low level alpha radiation emitter … linked to cancer when exposures are internal, [and] chemical toxicity causing kidney damage.” It added that “there is no dose so low that the probability of effect is zero.”

With evidence of its radio-toxicity so clear and redundant, any use of uranium weapons today appears to flaunt the military’s own Field Manual prohibition — absolute and universal — against the use of poison or poisoned weapons.

Historical Disregard Revisited

The military has a long history of deliberately exposing US citizens and others to deadly risks without their knowledge or consent, beginning with the open-air nuclear bomb tests it knew would contaminate vast areas. The Atomic Energy Commission (AEC) chose not to evacuate or even warn downwind populations it knew would be hard-hit by radioactive fallout. (“Fallout risk near atom tests was known, documents show,” New York Times, March 15, 1995) These bomb tests exposed Nevada Test Site workers to levels of radiation that the AEC knew could cause harm, but the agency chose not to reduce workers’ exposures or to even inform them of the risks because doing so would have scandalized and halted the bombing tests. (“Records say workers faced high radiation: Suit contends US used no safeguards,” St. Paul Pioneer Press, Dec. 14, 1989)

Likewise, the government refused to inform some 600,000 H-bomb factory workers that workplace radiation exposures posed serious health risks, although enough was known about radiation to warn them in 1948. (“N-plant workers not told of risks: Report says US arms program exposed many to radiation,” Associated Press, Dec. 19, 1989) Between 1944 and 1974, “medicalized” human radiation experiments were even conducted on unwitting US citizens, 16,000 of them (The Plutonium Files, by Eileen Welsome).

Today, the Pentagon extends this ghastly history into Syria where it is deliberately exposing human beings to weaponized radiation that it knows can cause cancer and other diseases. As if the undeclared, unconstitutional war in Syria weren’t unlawful enough, now add the crime of using poison in violation of military law and the Hague Regulations of War on Land.

It is so easy to prove that DU is poison, that a group of four non-lawyers, myself included, convinced a Minneapolis jury in 2004 that AlliantTechsystems’ manufacture of the shells is unlawful enough to excuse an otherwise illegal trespass; our minor offense was justified in order to prevent the greater harm of DU weapons production. Like torture, the use of such poison in war is always criminal, akin to gas war. This latest US government war crime must be condemned in the harshest terms.

For more information on DU weapons and the global effort to have them banned, see ICBUW.org.

This article was published by Counterpunch on October 28, 2016 and the Duluth Reader Weekly on October 27, 2016.

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Depleted Uranium

smallduposter

Related Articles from the Nukewatch Quarterly

Depleted Uranium: Weapon of Mass Destruction

In the 1991 Persian Gulf War, U.S. forces used depleted uranium as both armor piercing bullets and as tank armor for the first time. These weapons are both radioactive and toxic. Uranium Oxide particles formed during production, testing, and battlefield use pose a long term threat to human health and the environment.

Uranium weapons are effective antitank “penetrators” because they are extremely dense. A slug of uranium weighs twice as much as a piece of lead the same size. When alloyed with titanium, uranium is extremely hard. Uranium is also “pyrophoric”, which means it burns upon impact.

The U.S. Military chose to develop uranium weapons not only because they are promised to be effective, but because the metal itself is very cheap. Depleted uranium is material that remains when enriched fissionable uranium- that is, capable of generating a nuclear explosion or nuclear power- is separated from natural uranium. The U.S. stockpile exceeds a billion pounds. Uranium weapons production is the nuclear bombmakers’ idea of “recycling”.

The Agent Orange of the 90’s

Depleted Uranium is not capable of an atomic chain reaction. It is not considered a high-level radioactive material. As a metal slab, like the armor plates in the U.S. Army’s M1 Abrams tanks, it is a relatively harmless. Though constant exposure could cause problems. But especially in particulate form, it can be extremely hazardous.

When uranium weapons burn, when they corrode, and when they are machined, uranium oxide dust is created. When inhaled, small particles-those less than 5 millionths of a meter-can lodge in a human lung tissue, exposing the host to a growing dose of alpha radiation. This can cause lung cancer in people of all ages, and is particularly hazardous to children.

Uranium, like lead and other heavy metals, is a chemical poison. The ingestion of minute quantities of uranium in food or drinking water can cause irreparable damage to the kidneys. Some experts consider this is a greater risk than radiation from depleted uranium.

Uranium weapons may be the “Agent Orange of the 90’s” because large numbers of people, friend and foe are being exposed to uranium oxide dust. We won’t know for 20-30 years the full significance of that exposure, but by then it will be too late. Here are a few examples of that exposure:

The U.S. Military, which fired thousands of uranium shells during the Persian Gulf War, left at least 387 tons of spent uranium munitions in Kuwait and southern Iraq after the war. The U.S. Government believes, based upon weapons tests in the U.S. and general knowledge about wind patterns, that there is no health or environmental hazard, but it has not undertaken any study of battlefield areas.

After the Persian Gulf War, contaminated U.S. armored vehicles were prepared for disposal in the United States. The U.S. soldiers–at least 25– who handled those vehicles were not warned of DU hazards or wore any protective gear.

Army weapons testers at the Jefferson Proving Ground in Indiana fired DU rounds at soft targets-cloth or plywood- to avoid combustion. Still, only 22,000kg of the 91,000kg fired there between 1984 and 1992 were recovered in biannual clearance operations. The Army will have to strip away several feet of soil during decontamination. This will increase soil erosion and the migration of DU.

The NRC permitted Nellis Air Force Base to receive and process up to 77,000 lbs. of DU rounds. These rounds were used in testing on the base’s Range 63 using tanks as targets. In 1980, NL Industries Uranium Weapons factory in Clonie, New York was forced to close. Uranium particles were found as far as 26 miles downwind.

In 1981, workers at Aerojet’s TNS Uranium Weapons Plant in Jonesborough, Tennessee went on strike because of plant conditions that caused an epidemic of uranium poisoning.

At Nuclear Metals Inc., which manufactures uranium weapons in Concord, Massachusetts, radioactive materials have contaminated surface water, ground water, and land. Independent testing done by Citizens Research and Environmental Watch(CREW), a local grassroots organization, found DU 18 times the background level and up to 9/10ths of a mile away. Concord has the second highest level of thyroid cancer in the state, 2 1/2 times the state average. — Military Toxics Project

Related Links And Resources

Alexandra C. Miller is a senior scientist with the Armed Forces Radiobiology Research Institute and an assistant professor at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. Dr. Miller has numerous publications in the area of depleted uranium health hazards and is the author of Depleted Uranium, Properties, Uses, and Health Consequences from the CRC Press.

Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets

During the 1991 Persian Gulf War several US military personnel were wounded by shrapnel fragments consisting of depleted uranium. These fragments were treated as conventional shrapnel and were not surgically removed to spare excessive tissue damage. Uranium bioassays conducted over a year after the initial uranium injury indicated a significant increase in urine uranium levels above natural background levels. The potential mutagenic effects of depleted uranium are unknown. To assess the potential mutagenic effects of long-term exposure to internalized depleted uranium, Sprague-Dawley rats were implanted with depleted uranium and their urine and serum were evaluated for mutagenic potential at various times after pellet implantation using the Ames Salmonella reversion assay. Tantalum, an inert metal widely used in prosthetic devices was used for comparison. Enhancement of mutagenic activity in Salmonella typhiurium strain TA98 and the Ames II™ mixed strains (TA7001-7006) was observed in urine samples from animals implanted with depleted uranium pellets. In contrast, urine samples from animals implanted with tantalum did not show a significant enhancement of mutagenic activity in these strains. In depleted uranium-implanted animals, urine mutagenicity increased in a dose- and time-dependent manner demonstrating a strong positive correlation with urine uranium levels (r = 0.995, P < 0.001). There was no mutagenic enhancement of any bacterial strain detected in the sera of animals implanted with either depleted uranium or tantalum pellets. The results suggest that uranium content in the urine is correlated with urine mutagenicity and that urinary mutagenicity might be used as a biomarker to detect exposure to internalized uranium.

Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay

Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Published data from our laboratory have demonstrated that DU exposure in vitro to immortalized human osteoblast cells (HOS) is both neoplastically transforming and genotoxic. DU possesses both a radiological (alpha particle) and a chemical (metal) component. Since DU has a low-specific activity in comparison to natural uranium, it is not considered to be a significant radiological hazard. In the current study we demonstrate that DU can generate oxidative DNA damage and can also catalyze reactions that induce hydroxyl radicals in the absence of significant alpha particle decay. Experiments were conducted under conditions in which chemical generation of hydroxyl radicals was calculated to exceed the radiolytic 6 generation by 10 -fold. The data showed that markers of oxidative DNA base damage, thymine glycol and 8-deoxyguanosine could be induced from DU-catalyzed reactions of hydrogen peroxide and ascorbate similarly to those occurring in the presence of iron catalysts. DU was 6-fold more efficient than iron at catalyzing the oxidation of ascorbate at pH 7. These data not only demonstrate that DU at pH 7 can induced oxidative DNA damage in the absence of significant alpha particle decay, but also suggest that DU can induce carcinogenic lesions, e.g. oxidative DNA lesions, through interaction with a cellular oxygen species. Published by Elsevier Science Inc.

Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2)

Depleted uranium (DU) and heavy-metal tungsten alloys (HMTAs) are dense heavy-metals used primarily in military applications. Chemically similar to natural uranium, but depleted of the higher activity 235U and 234U isotopes, DU is a low specific activity, high-density heavy metal. In contrast, the non-radioactive HMTAs are composed of a mixture of tungsten (91–93%), nickel (3–5%), and cobalt (2–4%) particles. The use of DU and HMTAs in military munitions could result in their internalization in humans. Limited data exist however, regarding the long-term health effects of internalized DU and HMTAs in humans. Both DU and HMTAs possess a tumorigenic transforming potential and are genotoxic and mutagenic in vitro. Using insoluble DU-UO2 and a reconstituted mixture of tungsten, nickel, cobalt (rWNiCo), we tested their ability to induce stress genes in thirteen different recombinant cell lines generated from human liver carcinoma cells (HepG2). The commercially available CAT-Tox (L) cellular assay consists of a panel of cell lines stably transfected with reporter genes consisting of a coding sequence for chloramphenicol acetyl transferase (CAT) under transcriptional control by mammalian stress gene regulatory sequences. DU, (5–50 μg/ml) produced a complex profile of activity demonstrating significant dose-dependent induction of the hMTIIA FOS, p53RE, Gadd153, Gadd45, NFκBRE, CRE, HSP70, RARE, and GRP78 promoters. The rWNiCo mixture (5–50 μg/ml) showed dose-related induction of the GSTYA, hMTIIA, p53RE, FOS, NFκBRE, HSP70, and CRE promoters. An examination of the pure metals, tungsten (W), nickel (Ni), and cobalt (Co), comprising the rWNiCo mixture, demonstrated that each metal exhibited a similar pattern of gene induction, but at a significantly decreased magnitude than that of the rWNiCo mixture. These data showed a synergistic activation of gene expression by the metals in the rWNiCo mixture. Our data show for the first time that DU and rWNiCo can activate gene expression through several signal transduction pathways that may be
involved in the toxicity and tumorigenicity of both DU and HMTAs.

Transformation of Human Osteoblast Cells to the Tumorigenic Phenotype by Depleted Uranium-Uranyl Chloride

Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Although the health effects of occupational uranium exposure are well known, limited data exist regarding the long-term health effects of internalized DU in humans. We established an in vitro cellular model to study DU exposure. Microdosimetric assessment, determined using a Monte Carlo computer simulation based on measured intracellular adn extracellular uranium levels, showed that few (0.0014%) cell nuclei were hit by alpha particles. We report the ability of DU-uranyl chloride to transform immortalized human osteoblastic cells (HOS) to the tumorigenic phenotype. DU-uranyl chloride-transformants are characterized by anchorage-indeendent growth, tumor formation in mice, expression of high levels of the k-ras oncogene, reduced production of the Rb tumor-suppressor protein, and elevated levels of sister chromatid exchanges per cell. DU-uranyl chloride treatment resulted in a 9.6 (± 2.8) -fold increase in transformation frequency compared to untreated cells. In comparison, nickel sulfate resulted in a 7.1 (± 2.1) -fold increase in transformation frequency. This is the first report showing that a DU compound caused human cell transformation to the neoplastic phenotype. Although additional studies are needed to determine if protracted DU exposure produces tumors in vivio, the implication from these in vitro results is that the risk of cancer induction from internalized DU exposure may be comparable to other biologically reactive and carcinogenic heavy-metal compounds (e.g., nickel). Environ Health Perspect 106:465-471 (1998). [Online 6 July 1998]

http://ehpnet1.niehs.nih.gov/docs/1998/106p465-471miller/abstract.html

Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation

It is known that radiation can induce a transmissible persistent destabilization of the genome. We have established an in vitro cellular model using HOS cells to investigate whether genomic instability plays a role in depleted uranium (DU)-induced effects. Transmissible genomic instability, manifested in the progeny of cells exposed to ionizing radiation, has been characterized by de novo chromosomal aberrations, gene mutations, and an enhanced death rate. Cell lethality and micronuclei formation were measured at various times after exposure to DU, Ni, or gamma radiation. Following a prompt, concentration-dependent acute response for both endpoints, there was de novo genomic instability in progeny cells. Delayed reproductive death was observed for many generations (36 days, 30 population doublings) following exposure to DU, Ni, or gamma radiation. While DU stimulated delayed production of micronuclei up to 36 days after exposure, levels in cells exposed to gamma-radiation or Ni returned to normal after 12 days. There was also a persistent increase in micronuclei in all clones isolated from cells that had been exposed to nontoxic concentrations of DU. While clones isolated from gamma-irradiated cells (at doses equitoxic to metal exposure) generally demonstrated an increase in micronuclei, most clonal progeny of Ni-exposed cells did not. These studies demonstrate that DU exposure in vitro results in genomic instability manifested as delayed reproductive death and micronuclei formation.
Published by Elsevier Science Ltd.

Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium

Depleted uranium (DU) is a dense heavy metal used in military applications. During military conflicts, US military personnel have been wounded by DU shrapnel. The health effects of embedded DU are unknown. Published data from our laboratory demonstrated thatDUexposure in vitro can transform immortalized human osteoblast cells (HOS) to the tumorigenic phenotype. Results from our laboratory have also shown that DU is genotoxic and mutagenic in cultured human cells. Internalized DU could be a carcinogenic risk and concurrent alpha particle and heavy metal toxic effects complicate this potential risk. Anecdotal reports have suggested that DU can cause leukemia. To better assess this risk, we have developed an in vivo leukemogenesis model. This model involves using murine hematopoietic cells (FDC-P1) that are dependent on stimulation by granulocytemacrophage colony stimulating factor (GM-CSF) or interleukin 3 (IL-3) and injected into mice to produce myeloid leukemia. Although immortalized, these cells are not tumorigenic on subcutaneous inoculation in mice. Intravenous injection of FDC-P1 cells into DU-implanted DBA/2 mice was followed by the development of leukemias in 76% of all mice implanted with DU pellets. In contrast, only 12% of control mice developed leukemia. Karyotypic analysis confirmed that the leukemias originated from FDC-P1 cells. The growth properties of leukemic cells from bone marrow, spleen, and lymph node were assessed and indicate that the FDC-P1 cells had become transformed in vivo. The kidney, spleen, bone marrow, muscle, and urine showed significant elevations in tissue uranium levels prior to induction of leukemia. These results demonstrated that a DU altered in vivo environment may be involved in the pathogenesis of DU induced leukemia in an animal model. (Mol Cell Biochem 279: 97–104, 2005)

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